NCIt definition : The nitrate salt form of sertaconazole, a synthetic imidazole derivative with antifungal
property. Sertaconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation,
resulting in the accumulation of fungal 14 alpha-methyl sterols and the inhibition
of ergosterol synthesis, an essential component of the cell membrane of fungi. This
leads to a disruption of cell membrane permeability and leakage of adenine triphosphate
(ATP) and other constituents from fugal cells.;