Preferred Label : Selegiline Hydrochloride;
NCIt synonyms : L-deprenyl Hydrochloride; Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, Hydrochloride,(R)-;
NCIt definition : The hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of
phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO)
inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the
brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly
at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule.
This prevents the oxidative deamination of catecholamines and serotonin by MAO B,
and leads to an increase in these neurotransmitters' activities resulting in improved
motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron
and prolong dopamine activity.;
UNII : 6W731X367Q;
InChIKey : IYETZZCWLLUHIJ-UTONKHPSSA-N;
CAS number : 14611-52-0;
Drug name : Eldepryl; Emsam;
Chemical formula : C13H17N.HCl;
ChEBI ID : CHEBI:9087;
Origin ID : C47714;
UMLS CUI : C0700467;
See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
