Preferred Label : Rimexolone;
NCIt synonyms : (11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one;
NCIt definition : A derivative of prednisolone, a synthetic glucocorticoid with anti-inflammatory and
immunosuppressive property. Upon binding to the cytosolic glucocorticoid receptor
and cell entry, rimexolone activates specific glucocorticoid response elements, resulting
in altered gene expression. These include induction of synthesis of anti-inflammatory
protein IkappaB-alpha and inhibition of synthesis of nuclear factor kappaB (NFkappa
B). As a result, pro-inflammatory cytokine production such as interleukin-1 (IL-1),
IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation inhibited. Therefore,
an overall reduction in chronic inflammation and autoimmune reactions may be achieved.;
UNII : O7M2E4264D;
InChIKey : QTTRZHGPGKRAFB-OOKHYKNYSA-N;
CAS number : 49697-38-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 49697-38-3
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G-SRS /a ;
Drug name : Vexol;
Chemical formula : C24H34O3;
Origin ID : C47705;
UMLS CUI : C0140594;
- Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset