Rimexolone - CISMeF

Preferred Label : Rimexolone;

NCIt synonyms : (11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one;

NCIt definition : A derivative of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive property. Upon binding to the cytosolic glucocorticoid receptor and cell entry, rimexolone activates specific glucocorticoid response elements, resulting in altered gene expression. These include induction of synthesis of anti-inflammatory protein IkappaB-alpha and inhibition of synthesis of nuclear factor kappaB (NFkappa B). As a result, pro-inflammatory cytokine production such as interleukin-1 (IL-1), IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.;

UNII : O7M2E4264D;

InChIKey : QTTRZHGPGKRAFB-OOKHYKNYSA-N;

CAS number : 49697-38-3;

Drug name : Vexol;

Chemical formula : C24H34O3;

Details

Origin ID

C47705;

UMLS CUI

C0140594;

Automatic exact mappings (from CISMeF team)
- Product containing rimexolone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing rimexolone (medicinal product) [SNOMED CT concept]
- Rimexolone (substance) [SNOMED CT concept]
- rimexolone [ATC Code]
- rimexolone [ATC Code]
- rimexolone [Substance BNPC]
- rimexolone [MeSH concept]
- rimexolone [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- rimexolone [ATC Code]
- rimexolone [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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