Preferred Label : Pimecrolimus;
NCIt synonyms : 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 33-epi-Chloro-33-desoxyascomycin;
NCIt definition : A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property.
Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that
blocks the calcium-dependent signal transduction cascade mediated by calcineurin.
Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear
factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As
a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2)
type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked
and the expression of signals essential for the activation of inflammatory T-lymphocytes
is inhibited. However, pimecrolimus mode of action is cell-selective and does not
affect Langerhans' cells/dendritic cells and primary fibroblasts.;
UNII : 7KYV510875;
InChIKey : KASDHRXLYQOAKZ-XDSKOBMDSA-N;
CAS number : 137071-32-0;
Drug name : Elidel;
Chemical formula : C43H68ClNO11;
Origin ID : C47671;
UMLS CUI : C1099414;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
