NCIt definition : The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin
converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis,
perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE
and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated
vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal
cortex are inhibited and diuresis and natriuresis ensue.;