Paroxetine Mesylate

Preferred Label : Paroxetine Mesylate;

NCIt synonyms : Paroxetine Methanesulfonate; Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3S,4R)-, Methanesulfonate; (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Mesylate;

NCIt definition : The mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex, thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, which resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.;

UNII : M711N184JE;

InChIKey : SHIJTGJXUHTGGZ-RVXRQPKJSA-N;

CAS number : 217797-14-3;

Drug name : Pexeva;

Chemical formula : C19H20FNO3.CH4O3S;

Details

Origin ID

C47653;

UMLS CUI

C1365510;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Paroxetine mesilate (substance) [SNOMED CT concept]
- paroxetine mesylate [International Nonproprietary Name]
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- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
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- Paroxetine [NCIt concept]
is_salt_form_of
- Paroxetine [NCIt concept]

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