Preferred Label : Oxiconazole Nitrate;
NCIt synonyms : Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime,(Z)-,
Mononitrate; (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole
Mononitrate;
NCIt definition : The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal
activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole,
like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation
of lanosterol. This prevents the synthesis of ergosterol which is a crucial component
of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity,
oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular
components and eventually inhibits fungal cell growth.;
UNII : RQ8UL4C17S;
InChIKey : WVNOAGNOIPTWPT-NDUABGMUSA-N;
CAS number : 64211-46-7;
Drug name : Oxistat;
Chemical formula : C18H13Cl4N3O.HNO3;
Origin ID : C47644;
UMLS CUI : C0142160;
Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
