NCIt definition : The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic
agent with antihypotensive properties. Midodrine is converted to its active metabolite,
desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and
activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This
causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine
diffuses poorly across the blood-brain barrier, and is therefore not associated with
effects on the central nervous system.;