" /> Midodrine Hydrochloride - CISMeF





Preferred Label : Midodrine Hydrochloride;

NCIt synonyms : Amatine; Midamine; Gutron; 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride; ( -)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride;

NCIt definition : The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system.;

UNII : 59JV96YTXV;

InChIKey : MGCQZNBCJBRZDT-UHFFFAOYSA-N;

CAS number : 43218-56-0;

Drug name : ProAmantine;

Chemical formula : C12H18N2O4.HCl;

ChEBI ID : CHEBI:31847;

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28/07/2025


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