Preferred Label : Diflorasone Diacetate;
NCIt synonyms : 6alpha-Fluorobetamethasone-17,21 Diacetate; 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
17,21-Diacetate;
NCIt definition : The acetate salt form of diflorasone, a synthetic glucocorticoid with anti-inflammatory
and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the
cell by diffusion across the cell membrane and binds to the glucocorticoid receptor
(GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus
and activates or represses genes by interacting with short, palindromic DNA sequences
called glucocorticoid response element (GRE). Gene activation leads to the exertion
of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression
inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2
and IL-6, thereby preventing activation of cytotoxic T-lymphocytes.;
UNII : 7W2J09SCWX;
InChIKey : BOBLHFUVNSFZPJ-JOYXJVLSSA-N;
CAS number : 33564-31-7;
Drug name : Florone;
Chemical formula : C26H32F2O7;
ChEBI ID : CHEBI:31483;
Origin ID : C47488;
UMLS CUI : C0057992;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
