Preferred Label : Daunorubicin Citrate;
NCIt synonyms : 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,
(8S,10S)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);
NCIt definition : A semi-synthetic anthracycline glycoside antibiotic obtained from Streptomyces with
antineoplastic activity. Daunorubicin citrate intercalates DNA, which leads to inhibition
of DNA and RNA synthesis, and consequently blocks cell division and results in apoptosis.
This anti-tumor antibiotic is most active in the S phase of cell division. Daunorubicin
is indicated in the treatment of a wide variety of cancers including acute non-lymphocytic
leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor, and chronic myelocytic
leukemia. (NCI05);
UNII : 5L84T2Z6NP;
InChIKey : VNTHYLVDGVBPOU-QQYBVWGSSA-N;
CAS number : 371770-68-2;
Chemical formula : C27H29NO10.C6H8O7;
Origin ID : C47471;
UMLS CUI : C1289972;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
