Clocortolone Pivalate

Preferred Label : Clocortolone Pivalate;

NCIt synonyms : 9-Chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate;

NCIt definition : A glucocorticoid receptor agonist with metabolic, anti-inflammatory, and immunosuppressive activity. Clocortolone pivalate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished.;

UNII : QBL8IZH14X;

InChIKey : SXYZQZLHAIHKKY-GSTUPEFVSA-N;

CAS number : 34097-16-0;

Drug name : Cloderm;

Chemical formula : C27H36ClFO5;

ChEBI ID : CHEBI:59583;

Details

Origin ID

C47455;

UMLS CUI

C0055900;

Automatic exact mappings (from CISMeF team)
- Clocortolone pivalate (product) [Inactive SNOMED CT concept]
Currated CISMeF NLP mapping
- Clocortolone pivalate (substance) [SNOMED CT concept]
- clocortolone pivalate [MeSH concept]
- clocortolone pivalate [MeSH Supplementary Concept]
- clocortolone pivalate [SNOMED Notion]
Semantic type(s)
- Hormone [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clocortolone pivalate (product) [Inactive SNOMED CT concept]
- Clocortolone pivalate (substance) [SNOMED CT concept]
- clocortolone pivalate [MeSH concept]
- clocortolone pivalate [SNOMED Notion]
- clocortolone pivalate [MeSH Supplementary Concept]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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