NCIt definition : A synthetic glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory,
and immunosuppressive activity of the natural glucocorticoids. Amcinonide interacts
with specific corticosteroid receptors and was internalized, which leads to binding
of DNA and modification of gene expression. This results in synthesis of anti-inflammatory
mediators while inhibiting synthesis of inflammatory mediators. Consequently, an overall
reduction in chronic inflammation and autoimmune reactions are achieved.;