Preferred Label : Alclometasone Dipropionate;
NCIt synonyms : Delonal; Vaderm; 7a-Chloro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate; (7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione;
NCIt definition : The dipropionate salt form of alclometasone, a synthetic corticosteroid with low to
medium potency. Alclometasone dipropionate is a glucocorticoid receptor agonist that
mimics the metabolic, anti-inflammatory, immunosuppressive, antipruritic, and vasoconstrictive
effects of natural glucocorticoids. This drug interacts with specific intracellular
receptors and binds to DNA to modify gene expression. This results in an induction
of synthesis of certain proteins while inhibiting the synthesis of others. Alclometasone
dipropionate is used for the relief of the inflammatory and pruritic manifestations
of corticosteroid-responsive dermatoses. (NCI05);
UNII : S56PQL4N1V;
InChIKey : DJHCCTTVDRAMEH-DUUJBDRPSA-N;
CAS number : 66734-13-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 66734-13-2
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G-SRS /a ;
Drug name : Aclovate;
Molecule name : BRN 2317658;
Chemical formula : C28H37ClO7;
ChEBI ID : CHEBI:31184;
Origin ID : C47385;
UMLS CUI : C0051113;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
