Non-Secretory Multiple Myeloma

Preferred Label : Non-Secretory Multiple Myeloma;

NCIt synonyms : Non-Secretory Myeloma; Non-Secretory Plasma Cell Myeloma;

NCIt definition : A rare type of multiple myeloma in which the plasma cells synthesize but do not secrete immunoglobulins. As a result, none of the immunoglobulins appear out of the normal range. The symptoms are generally the same with those of immunoglobulin-secreting myeloma; however, the incidence of renal insufficiency is lower in non-secretory myeloma. The diagnosis can be missed because of the absence of monoclonal immunoglobulin in the serum or urine.;

Neoplastic status : Malignant;

Details

Origin ID

C4734;

UMLS CUI

C3898125;

Automatic exact mappings (from CISMeF team)
- Nonsecretory myeloma [MedDRA LLT]
Currated CISMeF NLP mapping
- Non-secretory myeloma (disorder) [SNOMED CT concept]
- non-secretory myeloma [DO Concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Bone Pain [NCIt concept]
- Hypercalcemia [NCIt concept]
- Lytic Metastatic Bone Lesion [NCIt concept]
- Pathologic Fracture [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Localized Lesion [NCIt concept]
- Monoclonal Gammopathy [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
disease_has_finding
- Aberrant Clonal Plasma Cell Population [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Plasma Cells Present in Bone Marrow [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Bone Marrow-Homing Plasma Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Plasma Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- t(11;14)(q13;q32) [NCIt concept]

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