Enalapril Maleate

Preferred Label : Enalapril Maleate;

NCIt synonyms : Enalapril;

NCIt definition : The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 9O25354EPJ;

InChIKey : OYFJQPXVCSSHAI-QFPUQLAESA-N;

CAS number : 76095-16-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 76095-16-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Renitec; Vasotec; Enacard;

Chemical formula : C20H28N2O5.C4H4O4;

ChEBI ID : CHEBI:4785;

Codes from synonyms : 32060;

Details

Origin ID

C468;

UMLS CUI

C0700452;

Automatic exact mappings (from CISMeF team)
- Enalapril [ICHI extension code]
Currated CISMeF NLP mapping
- Enalapril maleate [Substance BNPC]
- Enalapril maleate (substance) [SNOMED CT concept]
- enalapril maleate [MeSH concept]
- enalapril maleate [SNOMED Notion]
See also inter- (CISMeF)
- Enalapril maleate (product) [Inactive SNOMED CT concept]
- Product containing enalapril (medicinal product) [SNOMED CT concept]
- enalapril [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Enalapril [ICD-11 Extension code]
- Enalapril [LOINC component]
- Enalapril (substance) [SNOMED CT concept]
- enalapril [MeSH Descriptor]
- enalapril [MeSH concept]
- enalapril [SNOMED Notion]
- enalapril [Substance BNPC]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Enalapril [NCIt concept]
is_salt_form_of
- Enalapril [NCIt concept]

Keyword's position in hierarchy(ies) :

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