Preferred Label : Pentetic Acid;
NCIt synonyms : Diethylenetriamine Pentaacetic Acid; DTPA; Diethylenetriamine-N,N,N',N'',N''-pentaacetic Acid; Pentetate;
NCIt related terms : Detapac; (Diethylenetriamine)pentaacetic acid; Detarex;
NCIt definition : An edetate and a chelating agent used in preparing radiopharmaceuticals. Pentetic
acid (DTPA) has strong affinity for iron but also shows affinities for other heavy
metals, thereby is used in the treatment of iron-storage disease and poisoning from
heavy and radioactive metals. DTPA may chelate metallic moieties of unbound, extracellular
radioimmunotherapeutics, thereby aggregating radioimmunotherapeutics locally to higher
concentrations, and improving tumor cell radiocytotoxicity, while sparing normal tissues
from the radiocytotoxic effects. In addition, DTPA is used in radioimaing procedures
when complexes with radioisotopes, ex., Tc 99m or In 111.;
UNII : 7A314HQM0I;
InChIKey : QPCDCPDFJACHGM-UHFFFAOYSA-N;
CAS number : 67-43-6;
Drug name : Detarex; Detapac;
Chemical formula : C14H23N3O10;
NSC code : 7340;
ChEBI ID : CHEBI:35739;
Codes from synonyms : NSC0007340;
Origin ID : C460;
UMLS CUI : C0013254;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
