Preferred Label : MCF2 Oncoprotein;
Obsolete resource : true;
NCIt synonyms : DBL; MCF2;
NCIt definition : Human MCF2 Oncoprotein is a product of a mutated variant (Oncogene MCF2) of widely
expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66
Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor
that modulates the activity of small RHO GTPases by promoting conversion from GDP-
to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a
spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations
of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream
replacing sequence, URS, is derived from D15S93 at 15q15-q23. MCF2 Oncoprotein disrupts
normal cell function.;
NCIt note : See 'DBL Oncoprotein';
Concept status : Retired_Concept;
Origin ID : C45493;
UMLS CUI : C1706516;
OMIM relation
- Semantic type(s)
