t(2;22)(p23;q11)

Preferred Label : t(2;22)(p23;q11);

NCIt synonyms : t 2 22 p23 q11;

NCIt definition : A chromosomal translocation involving breakpoints within the p23 band on the short arm of chromosome 2 and the q11 band on the long arm of chromosome 22. This rearrangement is associated with MYH9-ALK or CLTCL1-ALK fusion gene expression and anaplastic large cell lymphoma.;

Details

Origin ID

C45441;

UMLS CUI

C1711148;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 2 [NCIt concept]
- Human Chromosome 22 [NCIt concept]
may_be_cytogenetic_abnormality_of_disease
- Childhood Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Refractory Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
molecular_abnormality_involves_gene
- ALK Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]

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