Phenoxybenzamine Hydrochloride

Preferred Label : Phenoxybenzamine Hydrochloride;

NCIt synonyms : Phenoxybenzamine; N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride;

NCIt definition : The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.;

UNII : X1IEG24OHL;

InChIKey : VBCPVIWPDJVHAN-UHFFFAOYSA-N;

CAS number : 63-92-3;

Drug name : Dibenzyline;

Chemical formula : C18H22ClNO.HCl;

NSC code : 37448;

Codes from synonyms : 06063;

Details

Origin ID

C44435;

UMLS CUI

C0242430;

Automatic exact mappings (from CISMeF team)
- Phenoxybenzamine [ICHI extension code]
- Product containing phenoxybenzamine (medicinal product) [SNOMED CT concept]
- phenoxybenzamine [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Phenoxybenzamine hydrochloride [Substance BNPC]
- Phenoxybenzamine hydrochloride (substance) [SNOMED CT concept]
- phenoxybenzamine hydrochloride [SNOMED Notion]
- phenoxybenzamine hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- Phenoxybenzamine [ICD-11 Extension code]
- Phenoxybenzamine (substance) [SNOMED CT concept]
- phenoxybenzamine [MeSH concept]
- phenoxybenzamine [SNOMED Notion]
- phenoxybenzamine [Substance BNPC]
- phenoxybenzamine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Phenoxybenzamine [NCIt concept]
is_salt_form_of
- Phenoxybenzamine [NCIt concept]

Keyword's position in hierarchy(ies) :

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