Dicer Pathway - CISMeF

Preferred Label : Dicer Pathway;

Alternative definition : BIOCARTA: The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interference (RNAi)], antisense transcription, or viral infection. In the current model for posttranscriptional gene silencing by RNAi, the ribonuclease III like enzyme Dicer processes dsRNA into small fragments (siRNA) of 21-25 nts. The siRNA is incorporated into the RNA-induced silencing complex (RISC), which targets and degrades the homologous mRNA. Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_dicerPathway;

Details

Origin ID

C39050;

UMLS CUI

C1511895;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Endoribonuclease Dicer [NCIt concept]
- Protein Argonaute-1 [NCIt concept]
- Protein Argonaute-2 [NCIt concept]
- Protein Argonaute-3 [NCIt concept]
- Protein Argonaute-4 [NCIt concept]
pathway_has_gene_element
- AGO1 wt Allele [NCIt concept]
- AGO2 wt Allele [NCIt concept]
- AGO3 wt Allele [NCIt concept]
- AGO4 wt Allele [NCIt concept]
- DICER1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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