Mu Heavy Chain Disease

Preferred Label : Mu Heavy Chain Disease;

NCIt definition : A clonal disorder characterized by the secretion of a mu heavy chain that lacks a variable region. Most patients present with slowly progressive chronic lymphocytic leukemia (CLL). In contrast to most cases of CLL, Mu heavy chain disease is associated with hepatosplenomegaly and absence of lymphadenopathy.;

Neoplastic status : Malignant;

Details

Origin ID

C3892;

UMLS CUI

C0242310;

Automatic exact mappings (from CISMeF team)
- Heavy chain disease [ICD-10 Sub-category]
- Heavy chain disease (morphologic abnormality) [SNOMED CT concept]
- Mu heavy chain disease [ICD-11 Extension code]
- Mu heavy chain disease [ICD-11 Subcategory]
- alpha heavy chain disease [SNOMED Notion]
- heavy chain disease [MeSH Descriptor]
- μ-Heavy chain disease [PASCAL descriptor]
Currated CISMeF NLP mapping
- Mu heavy chain disease (disorder) [SNOMED CT concept]
- Mu-heavy chain disease [ORDO Disease]
- mu-Chain disease [MeSH concept]
DO Cross reference
- heavy chain disease [DO Concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Hepatomegaly [NCIt concept]
- Splenomegaly [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Mu heavy chain disease (disorder) [SNOMED CT concept]
- Mu-heavy chain disease [ORDO Disease]
- mu chain disease [DO Concept]
- mu-Chain disease [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small Lymphocyte with Clumped Chromatin [NCIt concept]
disease_has_associated_disease
- Chronic Lymphocytic Leukemia [NCIt concept]
disease_has_finding
- Bone Marrow Involvement [NCIt concept]
- Defective Heavy Chain Present [NCIt concept]
- Defective Mu Heavy Chain Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Progressive Clinical Course [NCIt concept]
- Vacuolated Plasma Cells in the Bone Marrow [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]

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