Preferred Label : Muparfostat;
NCIt synonyms : Sulfated Phosphomanno-oligosaccharide PI-88; alpha-D-Mannan, (1- 3)-, 6-(Dihydrogen Phosphate) Tris(Hydrogen Sulfate); 6-O-(dihydrogen Phosphate)-2,3,4-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1-
poly(3)-2,4,6-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1- )2)-1,3,4,6-tetrakis-O-(hydrogen
Sulfate)-d-mannopyranose; Phosphomannopentose Sulfate PI-88;
NCIt related terms : PI-88;
NCIt definition : A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived
from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with
potential antiangiogenic activity. Muparfostat inhibits the endo-beta-D-glucuronidase
heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate
proteoglycans in extracellular matrices, an important step in the metastatic process.
This agent may also bind with high affinity to the heparan sulfate-binding domains
of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2,
thereby reducing their functional activities and inhibiting VEGF and FGF stimulation
of tumor angiogenesis. Increased heparanase activity has been implicated in tumor
angiogenesis and metastasis.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called antiangiogenesis agents.;
UNII : P2BKS6T40H;
CAS number : 1020105-89-8;
Molecule name : PI-88; PI 88;
Codes from synonyms : CDR0000346493;
Origin ID : C38690;
UMLS CUI : C0769628;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
