Heparanase - CISMeF

Preferred Label : Heparanase;

NCIt synonyms : Heparanase-1; HPSE; HPSE Protein; EC 3.2.1.166; Endo-Glucoronidase; Hpa1;

NCIt definition : Heparanase (543 aa, 61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism.;

NCIt note : Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation.;

Details

Origin ID

C26313;

UMLS CUI

C1505817;

Automatic exact mappings (from CISMeF team)
- HPA-1 [LOINC component]
- Heparanase [OMIM gene]
- Hpa I recognition polymorphism, beta-globin-related [OMIM Phenotype]
- heparanase [HGNC gene]
- platelet antibody hpa-1 [SNOMED Notion]
OMIM relation
- Heparanase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HPSE Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Coagulation Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- Muparfostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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