Rectal Route of Administration

Preferred Label : Rectal Route of Administration;

NCIt synonyms : Per Rectum; Rectal Route of Drug Administration;

NCIt related terms : RECTAL; Rectal use;

NCIt definition : The introduction of a substance into the gastrointestinal tract by the way of the rectum, usually for systemic action. Depending on the molecular structure, drugs cross the rectal wall via either intercellular or tight junctions interconnecting the mucosal cells. Drug absorption is usually around 50% of normal oral dose. Due to the drainage pattern of the rectal veins, the hepatic first-pass effect tends to increase as the dosage form is placed deeper into the rectum. Solid suppositories represent greater than 98% of all rectal dosage forms.;

Alternative definition : CDISC: Administration to the rectum. (FDA); EDQM-HC: Administration of a medicinal product to the rectum in order to obtain a local or systemic effect.;

FDA table : Route of Administration (C-DRG-00301);

Codes from synonyms : 016; 20061000;

Details

Origin ID

C38295;

UMLS CUI

C1527425;

Automatic exact mappings (from CISMeF team)
- Per rectum [LOINC part]
- Rectal (qualifier value) [SNOMED CT concept]
- Rectum [LOINC System]
- Rectum [LOINC System]
- rectum [MeSH Descriptor]
See also inter- (CISMeF)
- Administration of drug or medicament via rectal route (procedure) [SNOMED CT concept]
- Rectal (intended site) [SNOMED CT concept]
- administration, rectal [MeSH Descriptor]
- administration, rectal [MeSH concept]
- rectal [Radlex concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
UMLS correspondences (same concept)
- Administration of drug or medicament via rectal route (procedure) [SNOMED CT concept]
- Rectal route (qualifier value) [SNOMED CT concept]
- administration, rectal [MeSH concept]
- administration, rectal [MeSH Descriptor]
- per rectum [SNOMED Notion]
concept_is_in_subset
- CDISC CDASH Concomitant Medication Route of Administration Terminology [NCIt concept]
- CDISC CDASH Exposure Route of Administration Terminology [NCIt concept]
- CDISC CDASH Terminology [NCIt concept]
- CDISC SDTM Route of Administration Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CDISC SEND Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- EDQM Health Care Terminology [NCIt concept]
- EDQM-HC Routes and Methods of Administration Terminology [NCIt concept]
- FDA Structured Product Labeling Terminology [NCIt concept]
- SPL Drug Route of Administration Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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