Clonidine - CISMeF

Preferred Label : Clonidine;

NCIt related terms : N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine;

NCIt definition : An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.;

Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.;

UNII : MN3L5RMN02;

InChIKey : GJSURZIOUXUGAL-UHFFFAOYSA-N;

CAS number : 4205-90-7;

Drug name : Catapres-TTS;

Chemical formula : C9H9Cl2N3;

ChEBI ID : CHEBI:46631; CHEBI:46632; CHEBI:3757;

Codes from synonyms : CDR0000630972; 06643;

Details

Origin ID

C380;

UMLS CUI

C0009014;

Automatic exact mappings (from CISMeF team)
- Other antihypertensive drugs, not elsewhere classified [ICD-10 Sub-category (who)]
- cloNIDine [LOINC Challenge]
- pre dose cloNIDine [LOINC Challenge]
Currated CISMeF NLP mapping
- Clonidine [Substance BNPC]
- Clonidine [ICD-11 Extension code]
- Clonidine [ICHI extension code]
- Clonidine [SMS substance]
- Clonidine (substance) [SNOMED CT concept]
- cloNIDine [LOINC component]
- clonidine [MeSH Descriptor]
- clonidine [MeSH concept]
- clonidine [SNOMED Notion]
False automatic mappings
- Other antihypertensive drugs, not elsewhere classified [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of other antihypertensive drugs [ICD-10 Sub-category]
See also inter- (CISMeF)
- Product containing clonidine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clonidine [ICD-11 Extension code]
- Clonidine (substance) [SNOMED CT concept]
- Product containing clonidine (medicinal product) [SNOMED CT concept]
- cloNIDine [LOINC Challenge]
- cloNIDine [LOINC component]
- clonidine [ATC Code]
- clonidine [ATC Code]
- clonidine [ATC Code]
- clonidine [MeSH concept]
- clonidine [SNOMED Notion]
- clonidine [MeSH Descriptor]
Validated automatic mappings to BTNT
- clonidine [ATC Code]
- clonidine [ATC Code]
- clonidine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Clonidine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Clonidine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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