NCIt definition : An endogenous amino acid derivative produced by vertebrate animals and occurring primarily
in muscle cells. Creatine is important for energy storage; it is phosphorylated to
creatine phosphate, which serves as a phosphate donor in the conversion of ADP to
ATP and supplies energy necessary for muscle contraction. Dietary supplementation
with creatine may improve muscle wasting associated with cancer and other chronic
diseases.;
Alternative definition : NCI-GLOSS: A substance that is made by the body and used to store energy. It is being
studied in the treatment of weight loss related to cancer. It is derived from the
amino acid arginine.;