" /> Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene - CISMeF





Preferred Label : Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene;

NCIt synonyms : Pregerminal Center Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; CLL/SLL with Unmutated IGVH; Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain-Region Gene;

NCIt definition : A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years.;

Neoplastic status : Malignant;

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30/07/2025


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