Preferred Label : Cholera Toxin;
NCIt definition : Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting
of major components heavy A- and light B peptides (choleragenoid) that initiates a
signaling cascade in intestinal epithelial cells causing a dysfunction of chloride
channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia;
A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity,
cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04);
CAS number : 9012-63-9;
Origin ID : C368;
UMLS CUI : C0008356;
Semantic type(s)
- UMLS correspondences (same concept)
