Preferred Label : Cholera Toxin;
NCIt definition : Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting
of major components heavy A- and light B peptides (choleragenoid) that initiates a
signaling cascade in intestinal epithelial cells causing a dysfunction of chloride
channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia;
A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity,
cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04);
CAS number : 9012-63-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 9012-63-9
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G-SRS /a ;
Origin ID : C368;
UMLS CUI : C0008356;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
