Preferred Label : cholera toxin;
MeSH definition : An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy
(H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The
catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment
is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal
epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed
transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates
the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate
release of fluid and electrolytes from intestinal crypt cells.; An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy
(H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The
catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment
is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal
epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer
of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production
of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid
and electrolytes from intestinal crypt cells.;
MeSH synonym : cholera enterotoxin ct; exotoxin, cholera; toxin, cholera; enterotoxin ct, cholera; cholera exotoxin; choleragen;
CISMeF synonym : ct, cholera enterotoxin;
MeSH hyponym : procholeragenoid; cholera toxin protomer A; choleragenoid; Cholera Toxin Protomer B; Cholera Toxin B Subunit; Cholera Toxin A Subunit; Cholera Toxin B; Toxin B, Cholera; Cholera Toxin Subunit B; Cholera Toxin Subunit A; Cholera Toxin A; Toxin A, Cholera;
CISMeF hyponym : EC 2.4.2.31;
MeSH Related Number : cholera toxin protomer A; EC 2.4.2.31;
Registry Number MeSH : 9012-63-9;
Related CAS MeSH : EC 2.4.2.31 (Cholera toxin protomer A);
MeSH annotation : /antag permitted but consider also ANTITOXINS;
Wikipedia link : https://en.wikipedia.org/wiki/Cholera toxin;
Is substance : O;
Origin ID : D002772;
UMLS CUI : C0008356;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- zonulin [MeSH Supplementary Concept]
- See also
- See also (suggested by CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy
(H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The
catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment
is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal
epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed
transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates
the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate
release of fluid and electrolytes from intestinal crypt cells.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy
(H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The
catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment
is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal
epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer
of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production
of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid
and electrolytes from intestinal crypt cells.
