NCIt definition : Build-up of fatty material and calcium deposition in the arterial wall resulting in
partial or complete occlusion of the arterial lumen.;
Alternative definition : CDISC: A degenerative change that occurs within the tunica intima of large and small
arteries and is initially characterized by progressive accumulation of lipids, lipoproteins,
and free cholesterol in the intima and media, with accumulation of macrophages and
lymphocytes within and around the arterial wall, and later characterized by regions
of intimal thickening composed of smooth muscle cells, mucopolysaccharides, and hypocellular
collagen deposits. (INHAND);