Protein Phosphatase 2A Regulatory Protein

Preferred Label : Protein Phosphatase 2A Regulatory Protein;

NCIt synonyms : Protein Phosphatase Regulatory Protein; Protein Phosphatase 2A Regulatory Protein Subunit;

NCIt definition : A subunit of protein phosphatase 2A that serves as a scaffold for the formation and localization of the holoenzyme complex and plays a role in the modulation of substrate specificity.;

NCIt note : A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.;

Details

Origin ID

C34083;

UMLS CUI

C5206894;

Biochemical function of gene products
- Immunoglobulin-Binding Protein 1 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Protein Dephosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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