N-cym Protein - CISMeF

Preferred Label : N-cym Protein;

NCIt synonyms : MYCNOS; DNA-Binding Transcriptional Activator NCYM; N-myc Opposite Strand; DNA-Binding Transcriptional Activator; NCYM Protein; NCYM; DNA-Binding Transcriptional Activator-NCYM;

NCIt definition : N-cym protein (109 aa, 12 kDa) is encoded by the human MYCNOS gene. This protein may play a role in embryonic development.;

NCIt note : Expressed in fetal brain, lung, liver, and kidney by human NCYM Gene, 109-aa 12-kDa DNA-Binding Transcriptional Activator NCYM contains a helix-loop-helix motif and a basic region. NCYM may function as a DNA-binding protein during normal fetal development and is implicated in the pathogenesis of human tumors. The NCYM transcription unit is located on the opposite strand to NMYC, with extensive overlap between the 5-prime ends of the two units. NMYC and NCYM appear to be coregulated under basal growth conditions and in response to retinoic acid.;

Details

Origin ID

C33964;

UMLS CUI

C1333228;

OMIM relation
- Mycn, opposite strand [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYCNOS protein, human [MeSH concept]
- MYCNOS protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- MYCNOS Gene [NCIt concept]
- Regulatory Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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