NCIt definition : A partial or complete replacement of the bone marrow stroma by fibrous tissue. It
can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders
(chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute
panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement
by a metastatic tumor (e.g., metastatic breast carcinoma). --2003;
Alternative definition : NCI-GLOSS: A disorder in which the bone marrow is replaced by fibrous tissue.;