Preferred Label : Busulfan;
NCIt synonyms : Myeleukon; 1,4-Di(methanesulfonyloxy)butane; Bussulfam; BUS; 1,4-Di(methylsulfonyloxy)butane; 1,4-Bis(methanesulfonoxy)butane; Misulfan; Busulphan; Glyzophrol; Sulfabutin; 1,4-Butanediol Dimethylsulfonate; Myelosan; Busulfanum; Joacamine; 1,4-Bitanediol Dimethanesulfonate Esters; Tetramethylene Bis(methanesulfonate); Methanesulfonic Acid Tetramethylene Ester;
NCIt related terms : GT 41; Tetramethylene bis[methanesulfonate]; Mylecytan; Myeloleukon; Methanesulfonic acid, tetramethylene ester; Myleran; CB 2041; 1, 4-Bis[methanesulfonoxy]butane; Misulban;
NCIt definition : A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties.
Although its mechanism of action is not fully understood, busulfan appears to act
through the alkylation of DNA. Following systemic absorption of busulfan, carbonium
ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA
replication and RNA transcription. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called alkylating
agents.;
UNII : G1LN9045DK;
InChIKey : COVZYZSDYWQREU-UHFFFAOYSA-N;
CAS number : 55-98-1;
Drug name : Myleran; Mitosan; Mielucin; Misulban; Busulfex; Busilvex;
Molecule name : WR-19508; GT-41; CB-2041;
Chemical formula : C6H14O6S2;
NSC code : 750;
ChEBI ID : CHEBI:28901;
Codes from synonyms : CDR0000045410; NSC0000750; 80;
Origin ID : C321;
UMLS CUI : C0006463;
CISMeF manual mappings
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
