Broxuridine - CISMeF

Preferred Label : Broxuridine;

NCIt synonyms : Bromouridine; BrdU; 5-Bromo-2'-deoxyuridine; 5-BrdU; Bromodeoxyuridine; Bromo Deoxyuridine;

NCIt related terms : 5-Budr; 5-Bromodeoxyuridine; Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Bromouracil deoxyriboside;

NCIt definition : A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks.;

Alternative definition : NCI-GLOSS: A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.;

UNII : G34N38R2N1;

InChIKey : WOVKYSAHUYNSMH-RRKCRQDMSA-N;

CAS number : 59-14-3;

Drug name : Broxine; Neomark-BU; Neomark;

Chemical formula : C9H11BrN2O5;

NSC code : 38297;

ChEBI ID : CHEBI:472552;

Codes from synonyms : CDR0000045179; NSC0038297;

Details

Origin ID

C318;

UMLS CUI

C0006233;

Automatic exact mappings (from CISMeF team)
- 2'-bromo-2'-deoxyuridine [MeSH concept]
- 2'-bromo-2'-deoxyuridine [MeSH Supplementary Concept]
- 5-bromo-2'-deoxyuridine [OBI concept]
- 5-bromouridine [Substance BNPC]
- 5-bromouridine [MeSH Supplementary Concept]
- 5-bromouridine [MeSH concept]
- Broxuridine [ICHI extension code]
Currated CISMeF NLP mapping
- Broxuridine [ICD-11 Extension code]
- bromodeoxyuridine [Substance BNPC]
- bromodeoxyuridine [MeSH Descriptor]
- bromodeoxyuridine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Broxuridine [ICD-11 Extension code]
- bromodeoxyuridine [Substance BNPC]
- bromodeoxyuridine [MeSH concept]
- bromodeoxyuridine [MeSH Descriptor]
chemical_or_drug_has_mechanism_of_action
- Nucleoside Analogue Incorporation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Strand Break [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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