NCIt definition : A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated
from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce
molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded
breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate
oxidation, and alterations in prostaglandin synthesis and degradation.;
Alternative definition : NCI-GLOSS: A drug that is used to treat many types of cancer and is being studied
in the treatment of other types of cancer. It comes from the bacterium Streptomyces
verticillus. Blenoxane that damages DNA and may kill cancer cells. It is a type of
antineoplastic antibiotic.;
UNII : 7DP3NTV15T;
CAS number : 9041-93-4;
Drug name : Bleo-cell; BleMomycine; Bleocin; Oil Bleo; Blanoxan; Bleolem; Bleo-S;
ChEBI ID : CHEBI:34582;
Codes from synonyms : NSC0125066; CDR0000637626; CDR0000637625; 00636;