Gamma Heavy Chain Disease

Preferred Label : Gamma Heavy Chain Disease;

NCIt synonyms : Franklin's Disease;

NCIt related terms : Franklin disease;

NCIt definition : A clonal disorder characterized by the secretion of a truncated gamma chain. In most cases, it is associated with morphologic changes also seen in lymphoplasmacytic lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic lymphoma.;

Neoplastic status : Malignant;

Details

Origin ID

C3083;

UMLS CUI

C0018854;

Currated CISMeF NLP mapping
- Gamma heavy chain disease [ICD-11 Extension code]
- Gamma heavy chain disease [ICD-11 Subcategory]
- Gamma heavy chain disease [ICD-10 Sub-category (who)]
- Gamma heavy chain disease (disorder) [SNOMED CT concept]
- Gamma heavy chain disease (disorder) [Inactive SNOMED CT concept]
- Gamma heavy chain disease (disorder) [Inactive SNOMED CT concept]
- Gamma-heavy chain disease [ORDO Disease]
- Heavy chain disease [ICD-10 Sub-category]
- Heavy chain disease (morphologic abnormality) [SNOMED CT concept]
- IgG heavy chain paraproteinemia [HPO term]
- alpha heavy chain disease [SNOMED Notion]
- gamma heavy chain disease [DO Concept]
- gamma-Chain disease [MeSH concept]
- heavy chain disease [MeSH Descriptor]
- γ-Heavy chain disease [PASCAL descriptor]
DO Cross reference
- heavy chain disease [DO Concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Eosinophilia [NCIt concept]
- Fever [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Splenomegaly [NCIt concept]
- Weight Loss [NCIt concept]
False automatic mappings
- Gamma heavy chain disease (disorder) [SNOMED CT concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Lymphoplasmacytoid Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
- Neoplastic Small B-Lymphocyte [NCIt concept]
disease_has_associated_disease
- Lymphoplasmacytic Lymphoma [NCIt concept]
disease_has_finding
- Defective Gamma Heavy Chain Present [NCIt concept]
- Defective Heavy Chain Present [NCIt concept]
- Lymphoplasmacytic Infiltrate [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Peripheral B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_associated_disease
- Autoimmune Hemolytic Anemia [NCIt concept]
- Bacterial Infection [NCIt concept]
- Thrombocytopenia Due to Immune Destruction [NCIt concept]

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