NCIt definition : An inflammatory reaction usually caused by infectious organisms, foreign bodies, or
cholesterol deposits. It is characterized by the presence of epithelioid histiocytes
and chronic inflammation.;
Alternative definition : NICHD: A lesion characterized by the presence of epithelioid histiocytes and chronic
inflammation.; CDISC: An organized chronic inflammatory reaction characterized by the presence of
epithelioid macrophages. Giant cells and/or necrosis can be observed.;