Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains

Preferred Label : Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains;

NCIt synonyms : Transmembrane Adaptor Protein PAG; PAG; Transmembrane Adapter Protein PAG; Phosphoprotein Associated with GEMs; Transmembrane Phosphoprotein Cbp; Csk-Binding Protein;

NCIt definition : Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (423 aa, 47 kDa) is encoded by the human PAG1 gene. This protein is involved in the regulation of T-cell antigen receptor (TCR)-mediated and high affinity immunoglobulin epsilon receptor (FCER1)-mediated signaling in T-cells and mast cells, respectively.;

Détails

Origin ID

C30118;

UMLS CUI

C1335407;

OMIM relation
- Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PAG1 protein, human [MeSH Supplementary Concept]
- PAG1 protein, human [MeSH concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- PAG1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- BCR Immune Response Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- T-Cell Activation [NCIt concept]

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