Transmembrane Protease Serine 2

Preferred Label : Transmembrane Protease Serine 2;

NCIt synonyms : Epitheliasin; TMPRSS2; EC 3.4.21.-; Serine Protease 10; Transmembrane Protease Serine-2;

NCIt definition : Transmembrane protease serine 2 (492 aa, 54 kDa) is encoded by the human TMPRSS2 gene. This protein plays a role in proteolysis.;

NCIt note : Transmembrane protease serine 2 contains a type II transmembrane domain, an LDL-receptor class A domain, a scavenger receptor cysteine-rich (SRCR) domain, and a protease domain. The protease domain is thought to be cleaved, activated, and secreted after autocleavage.;

Details

Origin ID

C30110;

UMLS CUI

C1742865;

OMIM relation
- Transmembrane serine protease 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TMPRSS2 protein, human [MeSH concept]
- TMPRSS2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- TMPRSS2 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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