Toll-Like Receptor 3

Preferred Label : Toll-Like Receptor 3;

NCIt synonyms : TLR3; CD283 Antigen; Toll-Like Receptor-3;

NCIt definition : Toll-like receptor 3 (904 aa, 104 kDa) is encoded by the human TLR3 gene. This protein plays a role in binding to viral double-stranded RNA and modulation of antiviral responses.;

NCIt note : TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons.;

Details

Origin ID

C30104;

UMLS CUI

C1313494;

Currated CISMeF NLP mapping
- Toll-Like receptor 3 [MeSH concept]
- toll-like receptor 3 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR3 protein, human [MeSH concept]
- TLR3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR3 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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