Preferred Label : snRNP Structural Core Protein;
NCIt synonyms : Small Nuclear Ribonucleoprotein Particle Structural Core Protein; Sm Protein;
NCIt definition : The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and
U5, are essential components of the eukaryotic pre-mRNA splicing machinery. These
snRNPs share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2,
SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the
biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear
RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free
protein heterooligomers. The common proteins are referred to as Sm proteins because
they represent the major targets for the anti-Sm autoantibodies which are diagnostic
for SLE. (from OMIM and Swiss-Prot);
Origin ID : C30090;
UMLS CUI : C1337055;
Biochemical function of gene products
- Semantic type(s)
- gene_encodes_gene_product
- gene_product_is_physical_part_of
