Preferred Label : Experimental Allergic Encephalomyelitis;
NCIt synonyms : Experimental Autoimmune Encephalomyelitis; EAE;
NCIt definition : An autoimmune demyelinating disease of the central nervous system that is produced
experimentally in animals by the injection of homogenized brain or spinal cord in
Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the
hypersensitivity immune response which is characterized by focal areas of lymphocyte
and macrophage infiltration into the brain, associated with demyelination and destruction
of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used
as an animal model for demyelinating diseases of the human central nervous system
such as multiple sclerosis.;
Origin ID : C3006;
UMLS CUI : C0014072;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
