Preferred Label : encephalomyelitis, autoimmune, experimental;
MeSH definition : An experimental animal model for central nervous system demyelinating disease. Inoculation
with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein,
or purified central myelin triggers a T cell-mediated immune response directed towards
central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including
perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination
underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS,
ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to
a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27;
Raine CS, Textbook of Neuropathology, 2nd ed, p604-5);
MeSH synonym : autoimmune encephalomyelitis, experimental; experimental allergic encephalomyelitis; autoimmune experimental encephalomyelitis; experimental encephalomyelitis, autoimmune; allergic encephalomyelitis, experimental; experimental allergic encephalomyelitides; encephalomyelitis, experimental allergic; encephalomyelitis, experimental autoimmune; experimental autoimmune encephalomyelitis; encephalomyelitis, autoimmune experimental;
CISMeF synonym : encephalomyelitis, allergic;
Related MeSH term : Allergic Encephalomyelitis;
MeSH annotation : coordinate with specific demyelinating disease if pertinent; DF: ENCEPH ALLERGIC; coordinate with specific demyelinating disease if pertinent;
Wikipedia link : https://en.wikipedia.org/wiki/Encephalomyelitis, autoimmune, experimental;
Origin ID : D004681;
UMLS CUI : C0014072;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
An experimental animal model for central nervous system demyelinating disease. Inoculation
with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein,
or purified central myelin triggers a T cell-mediated immune response directed towards
central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including
perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination
underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS,
ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to
a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27;
Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
