Dr1-Associated Corepressor

Preferred Label : Dr1-Associated Corepressor;

NCIt synonyms : Negative Cofactor 2 Alpha; NC2-Alpha; DR1-Associated Protein-1; DR1-Associated Protein 1; DRAP1;

NCIt definition : Dr1-associated corepressor (205 aa, 22 kDa) is encoded by the human DRAP1 gene. This protein is involved in the repression of gene expression.;

NCIt note : DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes.;

Details

Origin ID

C29572;

UMLS CUI

C0388904;

OMIM relation
- Dr1-associated protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DRAP1 protein, human [MeSH Supplementary Concept]
- DRAP1 protein, human [MeSH concept]
gene_encodes_gene_product
- DRAP1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Histone Fold [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients