NCIt definition : The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor
agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha
1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A)
receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing
neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines
non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant
and myorelaxant activities in addition to a sedative-hypnotic activity.;
Alternative definition : NCI-GLOSS: A drug used to treat insomnia (inability to sleep), and anxiety. It is
a type of imidazopyridine (sedative hypnotic).;
UNII : WY6W63843K;
InChIKey : VXRDAMSNTXUHFX-CEAXSRTFSA-N;
CAS number : 99294-93-6;
Drug name : Ambien; Intermezzo;
Chemical formula : 2C19H21N3O.C4H6O6;
ChEBI ID : CHEBI:10126;
Codes from synonyms : CDR0000386237; CDR0000386236;