Zolpidem Tartrate

Preferred Label : Zolpidem Tartrate;

NCIt related terms : zolpidem; Ambien;

NCIt definition : The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity.;

Alternative definition : NCI-GLOSS: A drug used to treat insomnia (inability to sleep), and anxiety. It is a type of imidazopyridine (sedative hypnotic).;

UNII : WY6W63843K;

InChIKey : VXRDAMSNTXUHFX-CEAXSRTFSA-N;

CAS number : 99294-93-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 99294-93-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ambien; Intermezzo;

Chemical formula : 2C19H21N3O.C4H6O6;

ChEBI ID : CHEBI:10126;

Codes from synonyms : CDR0000386237; CDR0000386236;

Details

Origin ID

C29553;

UMLS CUI

C0724725;

Automatic exact mappings (from CISMeF team)
- Product containing zolpidem (medicinal product) [SNOMED CT concept]
- Zolpidem (substance) [SNOMED CT concept]
- zolpidem [ATC Code]
Currated CISMeF NLP mapping
- Zolpidem tartrate [Substance BNPC]
- Zolpidem tartrate (substance) [SNOMED CT concept]
- zolpidem tartrate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Zolpidem tartrate [Substance BNPC]
- Zolpidem tartrate (substance) [SNOMED CT concept]
- zolpidem tartrate [MeSH concept]
Validated automatic mappings to NTBT
- Zolpidem [LOINC component]
- Zolpidem [MeSH Descriptor]
- Zolpidem [ICD-11 Extension code]
- zolpidem [MeSH concept]
- zolpidem [SNOMED Notion]
- zolpidem [Substance BNPC]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Zolpidem [NCIt concept]
is_salt_form_of
- Zolpidem [NCIt concept]

Keyword's position in hierarchy(ies) :

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