Tenecteplase - CISMeF

Preferred Label : Tenecteplase;

NCIt synonyms : TNK-tPA;

NCIt definition : A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.;

UNII : WGD229O42W;

CAS number : 191588-94-0;

Drug name : TNKase;

Details

Origin ID

C29489;

UMLS CUI

C0872913;

Automatic exact mappings (from CISMeF team)
- TNK-tissue plasminogen activator [MeSH concept]
- TNK-tissue plasminogen activator [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing tenecteplase (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tenecteplase (medicinal product) [SNOMED CT concept]
- Tenecteplase [MeSH Descriptor]
- Tenecteplase (substance) [SNOMED CT concept]
- tenecteplase [ATC Code]
- tenecteplase [International Nonproprietary Name]
- tenecteplase [MeSH concept]
Validated automatic mappings to BTNT
- tenecteplase [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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