Sumatriptan Succinate

Preferred Label : Sumatriptan Succinate;

NCIt definition : The succinate salt form of sumatriptan, a member of the triptan class of compounds with anti-migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain.;

UNII : J8BDZ68989;

InChIKey : PORMUFZNYQJOEI-UHFFFAOYSA-N;

CAS number : 103628-48-4;

Drug name : Imitrex;

Chemical formula : C14H21N3O2S.C4H6O4;

ChEBI ID : CHEBI:64359;

Détails

Origin ID

C29470;

UMLS CUI

C0206599;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Sumatriptan (substance) [SNOMED CT concept]
- sumatriptan [MeSH Descriptor]
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- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
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- Sumatriptan [NCIt concept]
is_salt_form_of
- Sumatriptan [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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