NCIt definition : A synthetic salicylic acid derivative with affinity for connective tissues containing
elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in
the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and
salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase
and prostaglandin production and is used in the management of inflammatory bowel diseases.
(NCI04);