NCIt definition : The hydrochloride salt form of sotalol, an ethanolamine derivative with Class III
antiarrhythmic and antihypertensive properties. Sotalol hydrochloride is a nonselective
beta-adrenergic receptor and potassium channel antagonist. In the heart, this agent
inhibits chronotropic and inotropic effects thereby slowing the heart rate and decreasing
myocardial contractility. This agent also reduces sinus rate, slows conduction in
the atria and in the atrioventricular (AV) node and increases the functional refractory
period of the AV node. In the lungs, sotalol inhibits vasodilation and bronchodilation.
In addition, this agent inhibits renin release.;